Dr. Prashant Vilas Bhangui On Liver Transplantation


A Senior Marketing consultant within the Institute of Liver Transplantation and Regenerative Drugs at Medanta, Gurgaon, Dr. Prashant Bhangui has over 16 years of wealthy skilled expertise within the subject of Hepatobiliary Surgical procedure and Liver Transplantation. His areas of medical and analysis curiosity embody hepatocellular carcinoma, colorectal liver metastases and dwelling donor liver transplantation.

Widespread Interview Questions On Liver Transplantation

Listed below are some questions answered by Dr.Prashant Vilas Bhangui.

Query: Are there various kinds of strategies for performing liver transplantation?

Reply: After we discuss strategies, there are two sorts of liver transplants. In case of deceased donor liver transplantation, the entire liver is retrieved from a mind useless affected person if the household is keen, or the affected person had initially expressed his willingness to donate his organ after his dying attributable to a street accident, some sort of head harm and so forth when he has a beating coronary heart however licensed mind useless. There’s a authorized process by which he/she is usually a potential donor.

The opposite kind of liver transplantation which is extra generally practised within the East due to the lack of understanding of organ donation is Dwelling Donor Transplantation. Underneath this, a wholesome, voluntary dwelling donor donates part of his or her liver to avoid wasting the lifetime of a liked one.

Query: How does the surgical procedure of liver transplantation have an effect on the standard of life for the donor and the recipient?

Reply: It is very important know that the standard of lifetime of a affected person with the end-stage liver illness earlier than he undergoes a liver transplant is extraordinarily poor, with lethargy, anorexia, weight reduction. Liver failure makes the affected person weak and the one strategy to give a brand new life to the affected person is thru a liver transplant.

After we discuss post-transplantation, the recipients require shut to 2 months to fully get better after the liver transplant surgical procedure. The keep within the hospital post-liver transplant can be two to 2 and a half weeks. Often, to get again to regular life, it takes round two months. After that, he can get again to his routine life. For an preliminary interval of 3-4 months after the liver transplant, the recipient must be cautious and maintain infections because the dose of immunosuppression required after the transplant is normally excessive throughout this early interval, and therefore the recipient is prone to an infection.

So far as the donor is worried, they should be within the hospital for a few week. After a month, the donor needn’t take any remedy and is able to resume his routine exercise.

Query: Practically 7.5 lakhs of recent instances of hepatocellular carcinoma are reported annually globally. How do you handle such circumstances right here at Medanta? Are there therapy strategies in addition to transplantation of the liver to deal with this situation?

Reply: Hepatocellular carcinoma is a main most cancers of the liver. These are cancers which originate from the cells of the liver, that are known as hepatocytes. This is among the main causes of dying in sufferers with continual liver illness. It is very important do not forget that 90% of HCC happens in sufferers with a diseased liver, that’s in sufferers affected by viral hepatitis or liver cirrhosis. HCC is an ailment that requires a multi-disciplinary method for therapy, and the therapy ought to be personalised. HCC is a heterogeneous illness, with tumours various from a really small dimension, say 1-2cm, to very massive tumours that are about 10-12 cms in dimension; all of those want completely different therapy.

It’s typically mentioned that the one healing therapy for HCC is surgical procedure, both resection or liver transplantation. Resection is eradicating your entire tumour together with the a part of a standard liver. Liver transplant is taken into account to be one of the best oncological therapy, it cures the tumour and the underlying liver illness.

Aside from this, there are different choices accessible that are non-surgical. For instance, if a affected person has a tumour which is lower than 2-3 cm in dimension, radiofrequency ablation or microwave ablation can be utilized for the therapy. Along with this, different choices embody transarterial chemoembolisation (TACE), transarterial radioembolization (TARE), and systemic remedy like Sorafenib, Lenvatinib, Nivolumab.

Query: What are the most important misgivings amongst sufferers that have an effect on your follow?

Reply: Primarily crucial misgiving is the time the affected person takes to return to a hospital for a transplant. Many instances folks consider that they’ll proceed with the medicines for a really lengthy interval, even after they’ve a decompensated liver illness. Typically, it’s believed that if greater than 70-80% of your liver capabilities are deranged, then the physique begins creating the symptoms of liver failure. Regardless of that, some folks proceed to strive various medicines for the therapy. In such instances, both the success fee of transplant will scale back, or the issues will enhance, when the affected person presents late, with multiorgan dysfunction secondary to liver failure, or with poor efficiency standing.

The second facet is the idea that if an individual donates his/her organs, he/she can be born with out these organs in his/her subsequent life. That is one thing that stops folks from donating their organs even after their dying.

Query: Are there secondary sorts of liver cancers too?

Reply: Secondary liver tumours are the commonest kind of tumours of the liver. Secondary tumours are tumours of different organs which have unfold to the liver. The most typical amongst these is the colorectal cancers, which spreads to the liver. They unfold to the liver as there are a standard blood provide and drainage within the colorectal space and liver. The tumour cells unfold through the portal vein into the liver, sit there and begin rising.

For secondary liver tumours as properly, the therapy of alternative is surgical procedure to attempt to fully resect the tumours within the liver, to keep away from any additional development of the tumour cells.

Check out all the article in #CrediTalk series here.

About The Physician

Dr. Prashant Vilas Bhangui is a senior marketing consultant within the Institute of Liver Transplantation and Regenerative Drugs at Medanta – The Medicity, Gurugram. He has 16 years of wealthy expertise in his subject. He accomplished his MBBS from Goa Medical School in 2000, MS typically surgical procedure from Goa Medical School in 2004, European Inter-College Diploma in Hepato-Biliary-Pancreatic Cancers: Oncosurgical Methods from Universite Paris XI, France in 2009 and Masters in Hepatobiliary & Pancreatic Surgical procedure from Henri Bismuth Hepatobiliary Institute, Villejuif, France in 2009.

For a precedence appointment or extra data, contact us at +91 8010994994 or ebook an appointment with Dr. Prashant Vilas Bhangui right here

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